Semax is known for its neuroprotective, nootropic and neurorestorative properties. It is one type of heptapeptide and it is used in case of different medical conditions such as: transient ischemic attack, stroke, cognitive disorders, optic nerve disease, peptic ulcers and immune system related issues. Please note that though this medicine is widely used in Russia and Ukraine, the US FDA is yet to evaluate the same.
Semax works by rapidly increasing the levels of brain-derived neurotrophic factor and the signaling receptor TrkB as well. The medicine also plays a major part in elevating the serotonergic and dopaminergic brain systems. Some practitioners recommend its usage as an antidepressant as Semax can attenuate the behavioral effects of exposure to the chronic stress. Semax is found to inhibit enzymes which are involved in the degradation of enkephalins and some other endogenous regulatory peptides too.
One of the biggest advantages of Semax is that it has no interactions with other medicines and the side effects are not significant either. You will not get attracted to the same and there should not be any allergic reactions of Semax either. Please store Semax in room temperature, away from direct exposure to sun and don’t freeze the same.
Semax 1% 3 ml (1vial)
Dosage: nasal drops 1%
Description: Colorless clear liquid.
Pharmacotherapeutic group: Nootropic drugs.
ATC code - [N06BX]
Pharmacological propertie: Semax nasal drops 1% - The original synthetic peptide preparation, which is the analogue of a fragment of adrenocorticotropic hormone (AKTG4-10) (methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline) is completely devoid of hormonal activity. All the amino acids are L-shaped.
Pharmacodynamics: Semax has an original mechanism neurospecific action on the central nervous system (CNS). The drug affects the processes associated with memory formation and learning. Semax enhances attention in training and analysis of information, improves the consolidation of the memory trace, improves adaptation to hypoxia, cerebral ischemia, anesthesia and other damaging influences. The drug is practically non-toxic in single and prolonged use. Shows no allergic, embryotoxic, teratogenic and mutagenic properties. Has no local irritating action.
Pharmacokinetics. Absorbed from the mucosa of the nasal cavity, while digested to 60-70% in percenatge of active substance. Semax is quickly delivered to all organs and tissues, crosses the blood-brain barrier. When being injected into the blood, Semax undergoes fairly rapid degradation and removal from the body with urine.
Indications for use: Acute ischemic stroke.
Contraindications: Hypersensitivity to the drug. Acute mental status disorder, accompanied by anxiety, pregnancy, lactation, history of convulsions.
Side effects: Prolonged use may cause mild irritation of the nasal mucosa.
Semax applied intranasally, using a bottle sealed with a plastic cap-dropper.
Carefully cut off the tip of the pipette.
The cap should be tightly closed dropper - Fig. 2.
Turn the bottle and easily tap the bottom, wait for the liquid filled the entire space of pipette.
Remove the cap and a create light pressure on the wide part of the pipette, squeeze the required number of drops of the drug in the nasal passage.
Drug should be stored with tightly closed cap.
The volume of one drop equals to 0.05 ml (50 ml). One drop of standard solution contains 500 mg of active ingredient.
Release form: 3 ml vial, sealed with a plastic cap-dropper. Each vial with instructions for use.
Storage condition: in darkness, at a temperature not exceeding +10 ° C, avoid freezing. Keep out of reach of children.
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